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Inulin

 

Inulins are a group of naturally occurring polysaccharides produced by many types of plants, industrially most often extracted from chicory. The inulins belong to a class of dietary fibers known as fructans. Inulin is used by some plants as a means of storing energy and is typically found in roots or rhizomes. Most plants that synthesize and store inulin do not store other forms of carbohydrate such as starch. In the United States in 2018, the Food and Drug Administration approved inulin as a dietary fiber ingredient used to improve the nutritional value of manufactured food products. Using inulin to measure kidney function is the "gold standard" for comparison with other means of estimating glomerular filtration rate.


Yogurt Enriched with Inulin Ameliorated Reproductive Functions and Regulated Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Mice Tiange Li, Yue Zhang, Jiajia Song, Lijun Chen, Min Du, Xueying Mao Nutrients. 2022 Jan; 14(2): 279. Published online 2022 Jan 10. doi: 10.3390/nu14020279 PMCID: PMC8781812
Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients Camille Amadieu, Valentin Coste, Audrey M. Neyrinck, Victoria Thijssen, Quentin Leyrolle, Laure B. Bindels, Hubert Piessevaux, Peter Stärkel, Philippe de Timary, Nathalie M. Delzenne, Sophie Leclercq Gut Microbes. 2022; 14(1): 2007042. Published online 2021 Dec 20. doi: 10.1080/19490976.2021.2007042 PMCID: PMC8726664
Dietary calcium phosphate strongly impacts gut microbiome changes elicited by inulin and galacto-oligosaccharides consumption Jori Fuhren, Markus Schwalbe, Jos Boekhorst, Christiane Rösch, Henk A. Schols, Michiel Kleerebezem Microbiome. 2021; 9: 218. Published online 2021 Nov 4. doi: 10.1186/s40168-021-01148-0 PMCID: PMC8567720
Effects of prebiotic oligofructose-enriched inulin on gut-derived uremic toxins and disease progression in rats with adenine-induced chronic kidney disease Ebru Melekoglu, M. Alper Cetinkaya, S. Evrim Kepekci-Tekkeli, Oguz Kul, Gulhan Samur PLoS One. 2021; 16(10): e0258145. Published online 2021 Oct 6. doi: 10.1371/journal.pone.0258145 PMCID: PMC8494360
Dietary Inulin Regulated Gut Microbiota and Improved Neonatal Health in a Pregnant Sow Model Hao Li, Longteng Ma, Longlin Zhang, Nian Liu, Zhiqing Li, Fan Zhang, Xiang Liu, Xiaokang Ma Front Nutr. 2021; 8: 716723. Published online 2021 Aug 9. doi: 10.3389/fnut.2021.716723 PMCID: PMC8380823
Dietary Supplementation with Inulin Modulates the Gut Microbiota and Improves Insulin Sensitivity in Prediabetes Xiaojing Wang, Tong Wang, Qian Zhang, Li Xu, Xinhua Xiao Int J Endocrinol. 2021; 2021: 5579369. Published online 2021 Jun 29. doi: 10.1155/2021/5579369 PMCID: PMC8261184
Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel Kai Han, Jutaek Nam, Jin Xu, Xiaoqi Sun, Xuehui Huang, Olamide Animasahun, Abhinav Achreja, Jin Heon Jeon, Benjamin Pursley, Nobuhiko Kamada, Grace Y. Chen, Deepak Nagrath, James J. Moon Nat Biomed Eng. Author manuscript; available in PMC 2021 Dec 24.Published in final edited form as: Nat Biomed Eng. 2021 Nov; 5(11): 1377–1388. Published online 2021 Jun 24. doi: 10.1038/s41551-021-00749-2 PMCID: PMC8595497
Effects of Inulin Consumption on the Gut Microbiome During Fasting: A Pilot Study in Healthy Volunteers Kerstin Thriene, Lena Amend, Till Strowig, Karin Michels Curr Dev Nutr. 2021 Jun; 5(Suppl 2): 1186. Published online 2021 Jun 7. doi: 10.1093/cdn/nzab054_041 PMCID: PMC8181642
The Obscure Effect of Tribulus terrestris Saponins Plus Inulin on Liver Morphology, Liver Fatty Acids, Plasma Glucose, and Lipid Profile in SD Rats with and without Induced Type 2 Diabetes Mellitus Kamila Misiakiewicz-Has, Dominika Maciejewska-Markiewicz, Sylwia Rzeszotek, Anna Pilutin, Agnieszka Kolasa, Paweł Szumilas, Ewa Stachowska, Barbara Wiszniewska Int J Mol Sci. 2021 Aug; 22(16): 8680. Published online 2021 Aug 12. doi: 10.3390/ijms22168680 PMCID: PMC8395419
Assessing the effects of inulin‐type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta‐analysis of randomized controlled trials Liangkui Li, Peng Li, Li Xu Food Sci Nutr. 2021 Aug; 9(8): 4598–4616. Published online 2021 Jun 21. doi: 10.1002/fsn3.2403 PMCID: PMC8358370
Maternal Inulin Supplementation Alters Hepatic DNA Methylation Profile and Improves Glucose Metabolism in Offspring Mice Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang Front Physiol. 2020; 11: 70. Published online 2020 Feb 7. doi: 10.3389/fphys.2020.00070 PMCID: PMC7020697
Influence of Maternal Inulin-Type Prebiotic Intervention on Glucose Metabolism and Gut Microbiota in the Offspring of C57BL Mice Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang Front Endocrinol (Lausanne) 2019; 10: 675. Published online 2019 Oct 1. doi: 10.3389/fendo.2019.00675 PMCID: PMC6779716
Effects of the extract from roasted chicory (Cichorium intybus L.) root containing inulin-type fructans on blood glucose, lipid metabolism, and fecal properties Mie Nishimura, Tatsuya Ohkawara, Toshiyuki Kanayama, Kazuya Kitagawa, Hiroyuki Nishimura, Jun Nishihira J Tradit Complement Med. 2015 Jul; 5(3): 161–167. Published online 2015 Jan 20. doi: 10.1016/j.jtcme.2014.11.016 PMCID: PMC4488567
Inulin Improves Insulin Sensitivity, Changes Cecal Bile Acids, but Does Not Mitigate Hepatic Steatosis from an Obesogenic, High Fat Diet Bret Rust, Joseph Idso, Bryan Safratowich, Michael Bukowski, Huawei Zeng, Matthew Picklo Curr Dev Nutr. 2020 Jun; 4(Suppl 2): 655. Published online 2020 May 29. doi: 10.1093/cdn/nzaa049_048 PMCID: PMC7257546
Effects of Inulin Propionate Ester on Obesity-Related Metabolic Syndrome and Intestinal Microbial Homeostasis in Diet-Induced Obese Mice Xiaozhen Zhu, Xia Zhang, Xuelu Gao, Yuetao Yi, Yang Hou, Xianyao Meng, Chenchen Jia, Bo Chao, Wenyong Fan, Xinrui Li, Hanhan Zhang ACS Omega. 2020 Jun 9; 5(22): 12865–12876. Published online 2020 May 28. doi: 10.1021/acsomega.0c00649 PMCID: PMC7288568
The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: A randomized clinical trial in obese Mexican women. Alma Rosa Tovar, María del Carmen Caamaño, Sandra Garcia-Padilla, Olga Patricia García, Miguel Angel Duarte, Jorge L Rosado Nutr J. 2012; 11: 44. Published online 2012 Jun 18. doi: 10.1186/1475-2891-11-44 PMCID: PMC3489692
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