Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS)—also known as the renin–angiotensin–aldosterone axis—that mediates the volume of extracellular fluid (blood plasma, lymph and interstitial fluid) and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure.
Renin is not commonly referred to as a hormone, albeit it having a receptor, the (pro)renin receptor, also known as the renin receptor and prorenin receptor (see also below), as well as enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I.
In human anatomy, a hamstring (/ˈhæmstrɪŋ/) is any one of the three posterior thigh muscles in between the hip and the knee (from medial to lateral: semimembranosus , semitendinosus and biceps femoris ). The hamstrings are susceptible to injury. In quadrupeds, the hamstring is the single large tendon found behind the knee or comparable area.