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Hesperetin

 


Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review Md Sohel, Habiba Sultana, Tayeba Sultana, Md. Al Amin, Suraiya Aktar, Md. Chayan Ali, Zahed Bin Rahim, Md. Arju Hossain, Abdullah Al Mamun, Mohammad Nurul Amin, Raju Dash Heliyon. 2022 Jan; 8(1): e08815. Published online 2022 Jan 23. doi: 10.1016/j.heliyon.2022.e08815 PMCID: PMC8810372
Hesperetin Exhibits Anti-Inflammatory Effects on Chondrocytes via the AMPK Pathway to Attenuate Anterior Cruciate Ligament Transection-Induced Osteoarthritis Jiaqin Wu, Yuna Qian, Cheng Chen, Fan Feng, Lianhong Pan, Li Yang, Chunli Wang Front Pharmacol. 2021; 12: 735087. Published online 2021 Sep 16. doi: 10.3389/fphar.2021.735087 PMCID: PMC8481891
Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects Kah Min Yap, Mahendran Sekar, Yuan Seng Wu, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Lay Jing Seow, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria, Pei Teng Lum Saudi J Biol Sci. 2021 Dec; 28(12): 6730–6747. Published online 2021 Jul 21. doi: 10.1016/j.sjbs.2021.07.046 PMCID: PMC8626310
Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination—Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation Naila Rabbani, Mingzhan Xue, Martin O. Weickert, Paul J. Thornalley Nutrients. 2021 Jul; 13(7): 2374. Published online 2021 Jul 11. doi: 10.3390/nu13072374 PMCID: PMC8308792
Hesperetin suppresses LPS/high glucose-induced inflammatory responses via TLR/MyD88/NF-κB signaling pathways in THP-1 cells Aeri Lee, HyunJi Gu, Min-Hee Gwon, Jung-Mi Yun Nutr Res Pract. 2021 Oct; 15(5): 591–603. Published online 2021 May 4. doi: 10.4162/nrp.2021.15.5.591 PMCID: PMC8446685
Hesperetin attenuates silica-induced lung injury by reducing oxidative damage and inflammatory response Shuxian Li, Linlin Shao, Jinguo Fang, Juan Zhang, Yanqin Chen, Abrey J. Yeo, Martin F. Lavin, Gongchang Yu, Hua Shao Exp Ther Med. 2021 Apr; 21(4): 297. Published online 2021 Jan 28. doi: 10.3892/etm.2021.9728 PMCID: PMC7885076
Hesperetin Promotes Cisplatin−Induced Apoptosis of Gastric Cancer In Vitro and In Vivo by Upregulating PTEN Expression Pengzhan He, Jingjing Ma, Yinghui Liu, Huan Deng, Weiguo Dong Front Pharmacol. 2020; 11: 1326. Published online 2020 Aug 27. doi: 10.3389/fphar.2020.01326 PMCID: PMC7482524
Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders Amjad Khan, Muhammad Ikram, Jong Ryeal Hahm, Myeong Ok Kim Antioxidants (Basel) 2020 Jul; 9(7): 609. Published online 2020 Jul 10. doi: 10.3390/antiox9070609 PMCID: PMC7402130
Cytotoxic and Antimetastatic Activity of Hesperetin and Doxorubicin Combination Toward Her2 Expressing Breast Cancer Cells Ika Putri Nurhayati, Annisa Khumaira, Gagas Pradani Nur Ilmawati, Edy Meiyanto, Adam Hermawan Asian Pac J Cancer Prev. 2020 May; 21(5): 1259–1267. doi: 10.31557/APJCP.2020.21.5.1259 PMCID: PMC7541862
Bioinformatics and In Vitro Studies Reveal the Importance of p53, PPARG and Notch Signaling Pathway in Inhibition of Breast Cancer Stem Cells by Hesperetin Adam Hermawan, Muthi Ikawati, Annisa Khumaira, Herwandhani Putri, Riris Istighfari Jenie, Sonia Meta Angraini, Haruma Anggraini Muflikhasari Adv Pharm Bull. 2021 Feb; 11(2): 351–360. Published online 2020 Apr 19. doi: 10.34172/apb.2021.033 PMCID: PMC8046396
Hesperetin reverses P-glycoprotein-mediated cisplatin resistance in DDP-resistant human lung cancer cells via modulation of the nuclear factor-κB signaling pathway Wencui Kong, Xiaoming Ling, Ying Chen, Xiaoli Wu, Zhongquan Zhao, Wenwu Wang, Shuiliang Wang, Guoxiang Lai, Zongyang Yu Int J Mol Med. 2020 Apr; 45(4): 1213–1224. Published online 2020 Feb 5. doi: 10.3892/ijmm.2020.4485 PMCID: PMC7053858
Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-O-Amide Hesperetin Derivatives Yilong Zhang, Yan Zheng, Wen Shi, Yahui Guo, Tao Xu, Zeng Li, Cheng Huang, Jun Li Molecules. 2019 Oct; 24(20): 3663. Published online 2019 Oct 11. doi: 10.3390/molecules24203663 PMCID: PMC6832651
Synthesis of Daidzein Glycosides, α-Tocopherol Glycosides, Hesperetin Glycosides by Bioconversion and Their Potential for Anti-Allergic Functional-Foods and Cosmetics Yuya Fujitaka, Hiroki Hamada, Daisuke Uesugi, Atsuhito Kuboki, Kei Shimoda, Takafumi Iwaki, Yuya Kiriake, Tomohiro Saikawa Molecules. 2019 Aug; 24(16): 2975. Published online 2019 Aug 16. doi: 10.3390/molecules24162975 PMCID: PMC6721765
Two birds, one stone: hesperetin alleviates chemotherapy-induced diarrhea and potentiates tumor inhibition Yaping Yu, Ren Kong, Huojun Cao, Zheng Yin, Jiyong Liu, Xiang Nan, Alexandria T. Phan, Tian Ding, Hong Zhao, Stephen T.C. Wong Oncotarget. 2018 Jun 15; 9(46): 27958–27973. Published online 2018 Feb 23. doi: 10.18632/oncotarget.24563 PMCID: PMC6021345
Hesperetin protects against inflammatory response and cardiac fibrosis in postmyocardial infarction mice by inhibiting nuclear factor κB signaling pathway Bing Wang, Lianghai Li, Ping Jin, Mengqiu Li, Jianguo Li Exp Ther Med. 2017 Sep; 14(3): 2255–2260. Published online 2017 Jul 9. doi: 10.3892/etm.2017.4729 PMCID: PMC5609142
Hesperetin conjugated PEGylated gold nanoparticles exploring the potential role in anti-inflammation and anti-proliferation during diethylnitrosamine-induced hepatocarcinogenesis in rats Gokuladhas Krishnan, Jayakumar Subramaniyan, Pramila Chengalvarayan Subramani, Barath Muralidharan, Devaki Thiruvengadam Asian J Pharm Sci. 2017 Sep; 12(5): 442–455. Published online 2017 May 12. doi: 10.1016/j.ajps.2017.04.001 PMCID: PMC7032104
Biological Effects of Hesperetin on Interleukin-6/Phosphorylated Signal Transducer and Activator of Transcription 3 Pathway Signaling in Prostate Cancer PC3 Cells Moein Shirzad, Esfandiar Heidarian, Pezhman Beshkar, Mostafa Gholami-Arjenaki Pharmacognosy Res. 2017 Apr-Jun; 9(2): 188–194. doi: 10.4103/0974-8490.204655 PMCID: PMC5424561
The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration Deting Xue, Erman Chen, Wei Zhang, Xiang Gao, Shengdong Wang, Qiang Zheng, Zhijun Pan, Hang Li, Ling Liu Oncotarget. 2017 Mar 28; 8(13): 21031–21043. Published online 2017 Feb 18. doi: 10.18632/oncotarget.15473 PMCID: PMC5400563
Radioprotective effect of hesperetin against γ-irradiation-induced DNA damage and immune dysfunction in murine splenocytes Jung Ae Kang, Seon Hye Yoon, Jong Kook Rho, Beom-su Jang, Dae Seong Choi, Dong-Eun Lee, Eui-Baek Byun, Jongho Jeon, Sang Hyun Park Food Sci Biotechnol. 2016 Mar; 25(Suppl 1): 163–168. Published online 2016 Mar 31. doi: 10.1007/s10068-016-0114-7 PMCID: PMC6049422
Hesperetin liposomes for cancer therapy Joy Wolfram, Bronwyn Scott, Kathryn Boom, Jianliang Shen, Carlotta Borsoi, Krishna Suri, Rossella Grande, Massimo Fresta, Christian Celia, Yuliang Zhao, Haifa Shen, Mauro Ferrari Curr Drug Deliv. Author manuscript; available in PMC 2019 Aug 2.Published in final edited form as: Curr Drug Deliv. 2016; 13(5): 711–719. PMCID: PMC6677249
Leukocyte Production of Inflammatory Mediators Is Inhibited by the Antioxidants Phloretin, Silymarin, Hesperetin, and Resveratrol Jezrom B. Fordham, Afsar Raza Naqvi, Salvador Nares Mediators Inflamm. 2014; 2014: 938712. Published online 2014 Feb 24. doi: 10.1155/2014/938712 PMCID: PMC3953573
Hesperetin Activates the Notch1 Signaling Cascade, Causes Apoptosis, and Induces Cellular Differentiation in Anaplastic Thyroid Cancer Priyesh N. Patel, Xiao-Min Yu, Renata Jaskula-Sztul, Herbert Chen Ann Surg Oncol. Author manuscript; available in PMC 2014 Dec 1.Published in final edited form as: Ann Surg Oncol. 2014 Dec; 21(0 4): 497–504. Published online 2014 Jan 14. doi: 10.1245/s10434-013-3459-7 PMCID: PMC4097979
Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells Yong Yang, Joy Wolfram, Kathryn Boom, Xiaohong Fang, Haifa Shen, Mauro Ferrari Cell Biochem Funct. Author manuscript; available in PMC 2013 Nov 27.Published in final edited form as: Cell Biochem Funct. 2013 Jul; 31(5): 10.1002/cbf.2905. Published online 2012 Oct 8. doi: 10.1002/cbf.2905 PMCID: PMC3842231
Hesperetin, a Potential Therapy for Carcinoid Cancer Barbara Zarebczan, Scott N. Pinchot, Muthusamy Kunnimalaiyaan, Herbert Chen Am J Surg. Author manuscript; available in PMC 2012 Mar 1.Published in final edited form as: Am J Surg. 2011 Mar; 201(3): 329–333. doi: 10.1016/j.amjsurg.2010.08.018 PMCID: PMC3073682
Production of Hesperetin Glycosides by Xanthomonas campestris and Cyclodextrin Glucanotransferase and Their Anti-allergic Activities Kei Shimoda, Hiroki Hamada Nutrients. 2010 Feb; 2(2): 171–180. Published online 2010 Feb 9. doi: 10.3390/nu2020171 PMCID: PMC3257635
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