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Beta-glucan


β-glucans form a natural component of the cell walls of bacteria, fungi, yeast, and cereals such as oat and barley. Each type of beta-glucan comprises a different molecular backbone, level of branching, and molecular weight which affects its solubility and physiological impact. One of the most common sources of β(1,3)D-glucan for supplement use is derived from the cell wall of baker's yeast (Saccharomyces cerevisiae). β-glucans found in the cell walls of yeast contain a 1,3 carbon backbone with elongated 1,6 carbon branches. Other sources include seaweed, and various mushrooms, such as lingzhi, shiitake, chaga, and maitake, which are under preliminary research for their potential immune effects.




Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer Shimizu K, Watanabe S, Watanabe S, Matsuda K, Suga T, Nakazawa S, Shiratori K. Hepatogastroenterology. 2009 Jan-Feb;56(89):240-4. PMID: 19453066.
Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients Kodama N, Komuta K, Nanba H. J Med Food. 2003 Winter;6(4):371-7. doi: 10.1089/109662003772519949. PMID: 14977447.
Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells Kodama N, Komuta K, Sakai N, Nanba H. Biol Pharm Bull. 2002 Dec;25(12):1647-50. doi: 10.1248/bpb.25.1647. PMID: 12499658.
Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity Masuda Y, Nawa D, Nakayama Y, Konishi M, Nanba H. J Leukoc Biol. 2015 Dec;98(6):1015-25. doi: 10.1189/jlb.1A0814-415RR. Epub 2015 Aug 21. PMID: 26297795.
Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa Kodama N, Asakawa A, Inui A, Masuda Y, Nanba H. Oncol Rep. 2005 Mar;13(3):497-502. PMID: 15706424.
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