Skip to main content

ornithine



Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization Kali M. Pruss, Fatima Enam, Eric Battaglioli, Mary DeFeo, Oscar R. Diaz, Steven K. Higginbottom, Curt R. Fischer, Andrew J. Hryckowian, William Van Treuren, Dylan Dodd, Purna Kashyap, Justin L. Sonnenburg Nat Metab. 2022; 4(1): 19–28. Published online 2022 Jan 6. doi: 10.1038/s42255-021-00506-4 PMCID: PMC8803604
Longitudinal Metabolomics Reveals Ornithine Cycle Dysregulation Correlates With Inflammation and Coagulation in COVID-19 Severe Patients Tao Li, Nianzhi Ning, Bo Li, Deyan Luo, Enqiang Qin, Wenjing Yu, Jianxin Wang, Guang Yang, Nan Nan, Zhili He, Ning Yang, Saisai Gong, Jiajia Li, Aixia Liu, Yakun Sun, Zhan Li, Tianye Jia, Jie Gao, Wang Zhang, Yanyu Huang, Jun Hou, Ying Xue, Deyu Li, Zhen Wei, Liangyan Zhang, Boan Li, Hui Wang Front Microbiol. 2021; 12: 723818. Published online 2021 Dec 3. doi: 10.3389/fmicb.2021.723818 PMCID: PMC8678452
Dual Inhibition of Ornithine Decarboxylase and A1 Adenosine Receptor Efficiently Suppresses Breast Tumor Cells Hongyan Ma, Qizhang Li, Jing Wang, Jing Pan, Zhengding Su, Sen Liu Front Oncol. 2021; 11: 636373. Published online 2021 Mar 11. doi: 10.3389/fonc.2021.636373 PMCID: PMC7991832
Ornithine and breast cancer: a matched case–control study Jiayi Zhang, Baihui Tao, Yiran Chong, Shuang Ma, Gang Wu, Hailong Zhu, Yi Zhao, Shitao Zhao, Mengmeng Niu, Shutian Zhang, Tianyi Wang, Shuman Yang, Wenjing Qiao, Ann M. Vuong, Jincheng Li, Demiao Zhu, Wei Tao Sci Rep. 2020; 10: 15502. Published online 2020 Sep 23. doi: 10.1038/s41598-020-72699-9 PMCID: PMC7511971
Chemotherapy in a Breast Cancer Patient Heterozygous Carrier of Ornithine Transcarbamylase Deficiency Magda Palka-Kotlowska, Luis Cabezón-Gutiérrez, Sara Custodio-Cabello, PIlar Quijada-Fraile, Silvia Chumillas-Calzada Cureus. 2020 May; 12(5): e8301. Published online 2020 May 26. doi: 10.7759/cureus.8301 PMCID: PMC7317123
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy Renee C. Geck, Jackson R. Foley, Tracy Murray Stewart, John M. Asara, Robert A. Casero, Jr., Alex Toker J Biol Chem. 2020 May 8; 295(19): 6263–6277. Published online 2020 Mar 5. doi: 10.1074/jbc.RA119.012376 PMCID: PMC7212655
Effects of arginine and ornithine supplementation to a high‐protein diet on selected cellular immune variables in adult cats Nadine Paßlack, Barbara Kohn, Jürgen Zentek J Vet Intern Med. 2020 Mar; 34(2): 852–856. Published online 2020 Feb 21. doi: 10.1111/jvim.15736 PMCID: PMC7096607
Ornithine decarboxylase antizyme inhibitor 2 (AZIN2) is a signature of secretory phenotype and independent predictor of adverse prognosis in colorectal cancer Tuomas Kaprio, Tiina Rasila, Jaana Hagström, Harri Mustonen, Petri Lankila, Caj Haglund, Leif C. Andersson PLoS One. 2019; 14(2): e0211564. Published online 2019 Feb 15. doi: 10.1371/journal.pone.0211564 PMCID: PMC6377119
Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels—A Randomized, Double-Blind, Placebo-Controlled Trial Naoki Ito, Shinobu Seki, Fumitaka Ueda Mar Drugs. 2018 Dec; 16(12): 482. Published online 2018 Dec 3. doi: 10.3390/md16120482 PMCID: PMC6315531
Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses Kshipra Singh, Lori A. Coburn, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Chanjuan Shi, M. Kay Washington, Paula B. Luis, Claus Schneider, Alberto G. Delgado, M. Blanca Piazuelo, John L. Cleveland, Alain P. Gobert, Keith T. Wilson Cancer Res. Author manuscript; available in PMC 2019 Aug 1.Published in final edited form as: Cancer Res. 2018 Aug 1; 78(15): 4303–4315. Published online 2018 May 31. doi: 10.1158/0008-5472.CAN-18-0116 PMCID: PMC6072585
Ornithine decarboxylase as a therapeutic target for endometrial cancer Hong Im Kim, Chad R. Schultz, Andrea L. Buras, Elizabeth Friedman, Alyssa Fedorko, Leigh Seamon, Gadisetti V. R. Chandramouli, G. Larry Maxwell, André S. Bachmann, John I. Risinger PLoS One. 2017; 12(12): e0189044. Published online 2017 Dec 14. doi: 10.1371/journal.pone.0189044 PMCID: PMC5730160
Multi-omics analysis reveals that ornithine decarboxylase contributes to erlotinib resistance in pancreatic cancer cells Won-Jun Jang, Boyeon Choi, Sang-Hoon Song, Naeun Lee, Dong-Joon Kim, Sooyeun Lee, Chul-Ho Jeong Oncotarget. 2017 Nov 3; 8(54): 92727–92742. Published online 2017 Oct 6. doi: 10.18632/oncotarget.21572 PMCID: PMC5696217
Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications Dana M. Hardbower, Mohammad Asim, Paula B. Luis, Kshipra Singh, Daniel P. Barry, Chunying Yang, Meredith A. Steeves, John L. Cleveland, Claus Schneider, M. Blanca Piazuelo, Alain P. Gobert, Keith T. Wilson Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5): E751–E760. Published online 2017 Jan 17. doi: 10.1073/pnas.1614958114 PMCID: PMC5293075
Proliferation and motility of hepatocellular, pancreatic and gastric cancer cells grown in a medium without glucose and arginine, but with galactose and ornithine Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige Oncol Lett. 2017 Mar; 13(3): 1276–1280. Published online 2017 Jan 4. doi: 10.3892/ol.2017.5568 PMCID: PMC5403308
A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells Jun Koseki, Hidetoshi Matsui, Masamitsu Konno, Naohiro Nishida, Koichi Kawamoto, Yoshihiro Kano, Masaki Mori, Yuichiro Doki, Hideshi Ishii Sci Rep. 2016; 6: 20726. Published online 2016 Feb 11. doi: 10.1038/srep20726 PMCID: PMC4749963
Targeting ornithine decarboxylase by α-difluoromethylornithine inhibits tumor growth by impairing myeloid-derived suppressor cells Cong Ye, Zhe Geng, Donye Dominguez, Siqi Chen, Jie Fan, Lei Qin, Alan Long, Yi Zhang, Timothy M. Kuzel, Bin Zhang J Immunol. Author manuscript; available in PMC 2017 Jan 15.Published in final edited form as: J Immunol. 2016 Jan 15; 196(2): 915–923. Published online 2015 Dec 9. doi: 10.4049/jimmunol.1500729 PMCID: PMC4707077
Immunohistochemical Expression of Ornithine Decarboxylase, Diamine Oxidase, Putrescine, and Spermine in Normal Canine Enterocolic Mucosa, in Chronic Colitis, and in Colorectal Cancer Giacomo Rossi, Matteo Cerquetella, Graziano Pengo, Subeide Mari, Emilia Balint, Gabrio Bassotti, Nicolae Manolescu Biomed Res Int. 2015; 2015: 172756. Published online 2015 Oct 15. doi: 10.1155/2015/172756 PMCID: PMC4624879
Association between the ornithine decarboxylase G316A polymorphism and breast cancer survival LINPING XU, JIANPING LONG, PENG WANG, KANGDONG LIU, LING MAI, YONGJUN GUO Oncol Lett. 2015 Jul; 10(1): 485–491. Published online 2015 May 12. doi: 10.3892/ol.2015.3201 PMCID: PMC4487138
A New Mouse Model of Mild Ornithine Transcarbamylase Deficiency (spf-j) Displays Cerebral Amino Acid Perturbations at Baseline and upon Systemic Immune Activation Tatyana N. Tarasenko, Odrick R. Rosas, Larry N. Singh, Kara Kristaponis, Hilary Vernon, Peter J. McGuire PLoS One. 2015; 10(2): e0116594. Published online 2015 Feb 3. doi: 10.1371/journal.pone.0116594 PMCID: PMC4315515
Evaluation of ανβ3-Mediated Tumor Expression with a 99mTc-Labeled Ornithine-Modified RGD Derivative During Glioblastoma Growth In Vivo Irene Tsiapa, George Loudos, Eirini A. Fragogeorgi, Penelope Bouziotis, Dimitrios Psimadas, Stavros Xanthopoulos, Maria Paravatou-Petsotas, Lazaros Palamaris, Alexandra D. Varvarigou, Dimitris Karnabatidis, George C. Kagadis Cancer Biother Radiopharm. 2014 Dec 1; 29(10): 444–450. doi: 10.1089/cbr.2014.1672 PMCID: PMC4267765
Eflornithine (DFMO) Prevents Progression of Pancreatic Cancer by Modulating Ornithine Decarboxylase Signaling Altaf Mohammed, Naveena B. Janakiram, Venkateshwar Madka, Rebekah L. Ritchie, Misty Brewer, Laura Biddick, Jagan Mohan R. Patlolla, Michael Sadeghi, Stan Lightfoot, Vernon E. Steele, Chinthalapally V. Rao Cancer Prev Res (Phila) Author manuscript; available in PMC 2015 Dec 1.Published in final edited form as: Cancer Prev Res (Phila). 2014 Dec; 7(12): 1198–1209. Published online 2014 Sep 23. doi: 10.1158/1940-6207.CAPR-14-0176 PMCID: PMC4310684
Vector Sequences Are Not Detected in Tumor Tissue from Research Subjects with Ornithine Transcarbamylase Deficiency Who Previously Received Adenovirus Gene Transfer Li Zhong, Shaoyong Li, Mengxin Li, Jun Xie, Yu Zhang, Brendan Lee, Mark L. Batshaw, James M. Wilson, Guangping Gao Hum Gene Ther. 2013 Sep; 24(9): 814–819. Published online 2013 Aug 7. doi: 10.1089/hum.2013.118 PMCID: PMC3768231
Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites Candace S. Hayes, Karen DeFeo-Mattox, Patrick M. Woster, Susan K. Gilmour Amino Acids. Author manuscript; available in PMC 2018 May 16.Published in final edited form as: Amino Acids. 2014 Mar; 46(3): 543–552. Published online 2013 Jul 25. doi: 10.1007/s00726-013-1559-0 PMCID: PMC5953903
Meat consumption, ornithine decarboxylase gene polymorphism, and outcomes after colorectal cancer diagnosis Jason A. Zell, Bruce S. Lin, Argyrios Ziogas, Hoda Anton-Culver J Carcinog. 2012; 11: 17. Published online 2012 Nov 28. doi: 10.4103/1477-3163.104004 PMCID: PMC3516190
Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells Qingsong Zhu, Lihua Jin, Robert A. Casero, Nancy E. Davidson, Yi Huang Breast Cancer Res Treat. Author manuscript; available in PMC 2013 Jul 18.Published in final edited form as: Breast Cancer Res Treat. 2012 Nov; 136(1): 57–66. Published online 2012 Sep 14. doi: 10.1007/s10549-012-2235-x PMCID: PMC3715085
Knockdown of Ornithine Decarboxylase Antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells Alison V. Fraser, Andrew C. Goodwin, Amy Hacker-Prietz, Elizabeth Sugar, Patrick M. Woster, Robert A. Casero, Jr. Amino Acids. Author manuscript; available in PMC 2013 Feb 1.Published in final edited form as: Amino Acids. 2012 Feb; 42(2-3): 529–538. Published online 2011 Aug 4. doi: 10.1007/s00726-011-1030-z PMCID: PMC3240712
Ornithine Decarboxylase Antizyme Induces Hypomethylation of Genome DNA and Histone H3 Lysine 9 Dimethylation (H3K9me2) in Human Oral Cancer Cell Line Daisuke Yamamoto, Kaori Shima, Kou Matsuo, Takashi Nishioka, Chang Yan Chen, Guo-fu Hu, Akira Sasaki, Takanori Tsuji PLoS One. 2010; 5(9): e12554. Published online 2010 Sep 3. doi: 10.1371/journal.pone.0012554 PMCID: PMC2933235
Cytoplasmic Accumulation of the RNA-binding Protein HuR Stabilizes the Ornithine Decarboxylase Transcript in a Murine Nonmelanoma Skin Cancer Model Shannon L. Nowotarski, Lisa M. Shantz J Biol Chem. 2010 Oct 8; 285(41): 31885–31894. Published online 2010 Aug 3. doi: 10.1074/jbc.M110.148767 PMCID: PMC2951260
Targeting Ornithine Decarboxylase for the Prevention of Nonmelanoma Skin Cancer in Humans Craig A. Elmets, Mohammad Athar Cancer Prev Res (Phila) Author manuscript; available in PMC 2011 Jan 1.Published in final edited form as: Cancer Prev Res (Phila). 2010 Jan; 3(1): 8–11. doi: 10.1158/1940-6207.CAPR-09-0248 PMCID: PMC2926793
Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival Jason A. Zell, Argyrios Ziogas, Natalia Ignatenko, Jane Honda, Ning Qu, Alexander S. Bobbs, Susan L. Neuhausen, Eugene W. Gerner, Hoda Anton-Culver Clin Cancer Res. Author manuscript; available in PMC 2010 Oct 1.Published in final edited form as: Clin Cancer Res. 2009 Oct 1; 15(19): 6208–6216. Published online 2009 Sep 29. doi: 10.1158/1078-0432.CCR-09-0592 PMCID: PMC2769500
Effect of remedies for enhancing resistance and relieving blood stasis on metastasis in postoperative gastric cancer and ornithine decarboxylase levels Ping Bu World J Gastroenterol. 1997 Jun 15; 3(2): 129–130. Published online 1997 Jun 15. doi: 10.3748/wjg.v3.i2.129 PMCID: PMC4801921
Regulation of ornithine decarboxylase gene expression by the Wilms' tumor suppressor WT1. J A Moshier, M Skunca, W Wu, S M Boppana, F J Rauscher, 3rd, J Dosescu Nucleic Acids Res. 1996 Mar 15; 24(6): 1149–1157. doi: 10.1093/nar/24.6.1149 PMCID: PMC145756
Purification of Ornithine Decarboxylase‐inducing Factor from Cell‐free Ascites Fluid of Ehrlich Ascites Tumor and Its Characteristics Kiichi Imamura, Ziyuang Wang, Kikuno Murayama‐Oda, Hee‐Kyoung Kim, Takao Tsuji, Takehiko Tanaka Jpn J Cancer Res. 1991 Mar; 82(3): 315–324. doi: 10.1111/j.1349-7006.1991.tb01848.x PMCID: PMC5918395
Ornithine carbamoyltransferase genes and phaseolotoxin immunity in Pseudomonas syringae pv. phaseolicola Richard C. Peet, Nickolas J. Panopoulos EMBO J. 1987 Dec 1; 6(12): 3585–3591. PMCID: PMC553825
Activation of mouse epidermal tumor ornithine decarboxylase by GTP: evidence for different catalytic forms of the enzyme. T G O'Brien, O Hietala, K O'Donnell, M Holmes Proc Natl Acad Sci U S A. 1987 Dec; 84(24): 8927–8931. doi: 10.1073/pnas.84.24.8927 PMCID: PMC299664
alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin. C E Weeks, A L Herrmann, F R Nelson, T J Slaga Proc Natl Acad Sci U S A. 1982 Oct; 79(19): 6028–6032. doi: 10.1073/pnas.79.19.6028 PMCID: PMC347045
Local anesthetics inhibit induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. S H Yuspa, U Lichti, T Ben Proc Natl Acad Sci U S A. 1980 Sep; 77(9): 5312–5316. doi: 10.1073/pnas.77.9.5312 PMCID: PMC350048
Phaseolotoxin-insensitive ornithine carbamoyltransferase of Pseudomonas syringae pv. phaseolicola: basis for immunity to phaseolotoxin. B J Staskawicz, N J Panopoulos, N J Hoogenraad J Bacteriol. 1980 May; 142(2): 720–723. PMCID: PMC294059
Regulation of ornithine decarboxylase activity by corticotropin in adrenocortical tumor cell clones: roles of cyclic AMP and cyclic AMP-dependent protein kinase. J E Kudlow, P A Rae, N S Gutmann, B P Schimmer, G N Burrow Proc Natl Acad Sci U S A. 1980 May; 77(5): 2767–2771. doi: 10.1073/pnas.77.5.2767 PMCID: PMC349485
Dissociation of tumor promoter-stimulated ornithine decarboxylase activity and DNA synthesis in mouse epidermis in vivo and in vitro by fluocinolone acetonide, a tumor-promotion inhibitor. U Lichti, T J Slaga, T Ben, E Patterson, H Hennings, S H Yuspa Proc Natl Acad Sci U S A. 1977 Sep; 74(9): 3908–3912. doi: 10.1073/pnas.74.9.3908 PMCID: PMC431781
Dissociation of increases in levels of 3':5'-cyclic AMP and 3':5'-cyclic GMP from induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in mouse epidermis in vivo. R A Mufson, E G Astrup, R C Simsiman, R K Boutwell Proc Natl Acad Sci U S A. 1977 Feb; 74(2): 657–661. doi: 10.1073/pnas.74.2.657 PMCID: PMC392351
webmd - ornithine
Food Healing Science - AZSP Healing
Labels:

Popular posts from this blog

TRPV1

The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor potential protein group. This protein is a member of the TRPV group of transient receptor potential family of ion channels. The function of TRPV1 is detection and regulation of body temperature. In addition, TRPV1 provides a sensation of scalding heat and pain (nociception). In primary afferent sensory neurons, it cooperates with TRPA1 (a chemical irritant receptor) to mediate the detection of noxious environmental stimuli.
Read more

Zen

Zen (Chinese: 禪; pinyin: Chán; Japanese: 禅, romanized: zen; Korean: 선, romanized: Seon; Vietnamese: Thiền) is a school of Mahayana Buddhism that originated in China during the Tang dynasty, known as the Chan School (Chánzong 禪宗), and later developed into various sub-schools and branches. From China, Chán spread south to Vietnam and became Vietnamese Thiền, northeast to Korea to become Seon Buddhism, and east to Japan, becoming Japanese Zen. The term Zen is derived from the Japanese pronunciation of the Middle Chinese word 禪 (chán), an abbreviation of 禪那 (chánnà), which is a Chinese transliteration of the Sanskrit word dhyāna ("meditation"). Zen emphasizes rigorous self-restraint, meditation-practice, insight into the nature of mind (見性, Ch. jiànxìng, Jp. kensho, "perceiving the true nature") and nature of things (without arrogance or egotism), and the personal expression of this insight in daily life, especially for the benefit of others. As such, it de-em...
Read more

Sulforaphane

Related Articles Houghton C. A. (2019). Sulforaphane: Its "Coming of Age" as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Oxidative medicine and cellular longevity, 2019, 2716870. https://doi.org/10.1155/2019/2716870 Santín-Márquez, R., Alarcón-Aguilar, A., López-Diazguerrero, N. E., Chondrogianni, N., & Königsberg, M. (2019). Sulforaphane - role in aging and neurodegeneration. GeroScience, 41(5), 655–670. https://doi.org/10.1007/s11357-019-00061-7 Mahn, A.; Castillo, A. Potential of Sulforaphane as a Natural Immune System Enhancer: A Review. Molecules 2021, 26, 752. https://doi.org/10.3390/molecules26030752 Liang J, Jahraus B, Balta E, Ziegler JD, Hübner K, Blank N, Niesler B, Wabnitz GH and Samstag Y (2018) Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione. Front. Immunol. 9:2584. doi: 10.3389/fimmu.2018.02584 Zimme...
Read more