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Insulin-like growth factor 1

Insulin-like growth factor 1 (IGF-1) , also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. IGF-1 is a protein that in humans is encoded by the IGF1 gene. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7,649 Daltons. In dogs, an ancient mutation in IGF1 is the primary cause of the toy phenotype. IGF-1 is produced primarily by the liver. Production is stimulated by growth hormone (GH). Most of IGF-1 is bound to one of 6 binding proteins (IGF-BP). IGFBP-1 is regulated by insulin. IGF-1 is produced throughout life; the highest rates of IGF-1 production occur during the pubertal growth spurt. The lowest levels occur in infancy and old age. A synthetic analog of IGF-1, mecasermin, is used in children for the treatment of growth failure.
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Sulforaphane

Related Articles Houghton C. A. (2019). Sulforaphane: Its "Coming of Age" as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Oxidative medicine and cellular longevity, 2019, 2716870. https://doi.org/10.1155/2019/2716870 Santín-Márquez, R., Alarcón-Aguilar, A., López-Diazguerrero, N. E., Chondrogianni, N., & Königsberg, M. (2019). Sulforaphane - role in aging and neurodegeneration. GeroScience, 41(5), 655–670. https://doi.org/10.1007/s11357-019-00061-7 Mahn, A.; Castillo, A. Potential of Sulforaphane as a Natural Immune System Enhancer: A Review. Molecules 2021, 26, 752. https://doi.org/10.3390/molecules26030752 Liang J, Jahraus B, Balta E, Ziegler JD, Hübner K, Blank N, Niesler B, Wabnitz GH and Samstag Y (2018) Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione. Front. Immunol. 9:2584. doi: 10.3389/fimmu.2018.02584 Zimme...
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Gluten-free diet

  Since gluten and starch from wheat flour would become sticky with certain amount of water, it is as same as kneading flour for making bread, its viscous of ingested foods is very depending on amount of fluid. 90% of fluid would be absorbed during digestion, it makes stool harden as well. And during digenstion process, amount of fluid is vary because of secretion of digestive juices and absorption/reabsorption of fluid. Since, the viscous of ingested gluten containing foods are very sensitive with amount of fluid, after absorption/reabsorption in small intestine, and because of the viscous of digesting foods containing gluten become higher. The higher viscous digesting foods and gluten sensitivity could make damages to intestine. Those repeated damages, inflamation and also body reaction because of the damages could cause the coeliac disease. The intestine environment of people who keep ingesting gluten, would be worse. Because of gluten itself is fine-particle and th...
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Qigong

Related Articles A comprehensive review of health benefits of qigong and tai chi. Jahnke R, Larkey L, Rogers C, Etnier J, Lin F. Am J Health Promot. 2010;24(6):e1-e25. doi:10.4278/ajhp.081013-LIT-248 PMCID: PMC3085832 Qigong in Cancer Care: Theory, Evidence-Base, and Practice . Klein P. Medicines (Basel). 2017 Jan 12;4(1):2. doi: 10.3390/medicines4010002. PMID: 28930219; PMCID: PMC5597070. Qigong for cancer treatment: a systematic review of controlled clinical trials Lee MS, Chen KW, Sancier KM, Ernst E. Acta Oncol. 2007;46(6):717-22. doi: 10.1080/02841860701261584. PMID: 17653892 The Effectiveness of Traditional Chinese Yijinjing Qigong Exercise for the Patients With Knee Osteoarthritis on the Pain, Dysfunction, and Mood Disorder: A Pilot Randomized Controlled Trial Shuaipan Zhang, Guangxin Guo, Xing Li, Fei Yao, Zhiwei Wu, Qingguang Zhu, Min Fang Front Med (Lausanne) 2021; 8: 792436. Published online 2022 Jan 11. doi: ...
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ornithine

Related Articles Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization Kali M. Pruss, Fatima Enam, Eric Battaglioli, Mary DeFeo, Oscar R. Diaz, Steven K. Higginbottom, Curt R. Fischer, Andrew J. Hryckowian, William Van Treuren, Dylan Dodd, Purna Kashyap, Justin L. Sonnenburg Nat Metab. 2022; 4(1): 19–28. Published online 2022 Jan 6. doi: 10.1038/s42255-021-00506-4 PMCID: PMC8803604 Longitudinal Metabolomics Reveals Ornithine Cycle Dysregulation Correlates With Inflammation and Coagulation in COVID-19 Severe Patients Tao Li, Nianzhi Ning, Bo Li, Deyan Luo, Enqiang Qin, Wenjing Yu, Jianxin Wang, Guang Yang, Nan Nan, Zhili He, Ning Yang, Saisai Gong, Jiajia Li, Aixia Liu, Yakun Sun, Zhan Li, Tianye Jia, Jie Gao, Wang Zhang, Yanyu Huang, Jun Hou, Ying Xue, Deyu Li, Zhen Wei, Liangyan Zhang, Boan Li, Hui Wang Front Microbiol. 2021; 12: 723818. Published online 2021 Dec 3. doi: 10.3389/fmicb.2021.723818 PMCID: PMC8678452 Dual Inhi...
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