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Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance Jan Gojda, Monika Cahova Biomolecules. 2021 Oct; 11(10): 1414. Published online 2021 Sep 28. doi: 10.3390/biom11101414 PMCID: PMC8533624A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents Sofia Moran-Ramos, Luis Macias-Kauffer, Blanca E. López-Contreras, Hugo Villamil-Ramírez, Elvira Ocampo-Medina, Paola León-Mimila, Blanca E. del Rio-Navarro, Omar Granados-Portillo, Isabel Ibarra-Gonzalez, Marcela Vela-Amieva, Armando R. Tovar, Nimbe Torres, Francisco J. Gomez-Perez, Carlos Aguilar-Salinas, Samuel Canizales-Quinteros Mol Med. 2021; 27: 108. Published online 2021 Sep 15. doi: 10.1186/s10020-021-00371-7 PMCID: PMC8444488
Krüppel-like factor 6–mediated loss of BCAA catabolism contributes to kidney injury in mice and humans Sian E. Piret, Yiqing Guo, Ahmed A. Attallah, Sylvia J. Horne, Amy Zollman, Daniel Owusu, Justina Henein, Viktoriya S. Sidorenko, Monica P. Revelo, Takashi Hato, Avi Ma’ayan, John Cijiang He, Sandeep K. Mallipattu Proc Natl Acad Sci U S A. 2021 Jun 8; 118(23): e2024414118. Published online 2021 May 31. doi: 10.1073/pnas.2024414118 PMCID: PMC8201852
Easy clinical predictor for low BCAA to tyrosine ratio in chronic liver disease patients with hepatocellular carcinoma: Usefulness of ALBI score as nutritional prognostic marker Atsushi Hiraoka, Masaya Kato, Kaori Marui, Taisei Murakami, Kei Onishi, Tomoko Adachi, Junko Matsuoka, Hidetaro Ueki, Takeaki Yoshino, Miho Tsuruta, Toshihiko Aibiki, Tomonari Okudaira, Taira Kuroda, Ryuichiro Iwasaki, Yoshifumi Suga, Hideki Miyata, Tomoyuki Ninomiya, Masashi Hirooka, Masanori Abe, Bunzo Matsuura, Kojiro Michitaka, Yoichi Hiasa Cancer Med. 2021 Jun; 10(11): 3584–3592. Published online 2021 May 7. doi: 10.1002/cam4.3908 PMCID: PMC8178498
Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever Takeshi Yoneshiro, Naoya Kataoka, Jacquelyn M Walejko, Kenji Ikeda, Zachary Brown, Momoko Yoneshiro, Scott B Crown, Tsuyoshi Osawa, Juro Sakai, Robert W McGarrah, Phillip J White, Kazuhiro Nakamura, Shingo Kajimura eLife. 2021; 10: e66865. Published online 2021 May 4. doi: 10.7554/eLife.66865 PMCID: PMC8137140
Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons Adriana Caldo-Silva, Guilherme Eustáquio Furtado, Matheus Uba Chupel, André L. L. Bachi, Marcelo P. de Barros, Rafael Neves, Emanuele Marzetti, Alain Massart, Ana Maria Teixeira Nutrients. 2021 Apr; 13(4): 1106. Published online 2021 Mar 28. doi: 10.3390/nu13041106 PMCID: PMC8066027
Gentamicin Induced Microbiome Adaptations Associate With Increased BCAA Levels and Enhance Severity of Influenza Infection Yakun Sun, Zhili He, Jiajia Li, Saisai Gong, Shunzong Yuan, Tao Li, Nianzhi Ning, Li Xing, Liangyan Zhang, Fanghong Chen, Zhan Li, Jianxin Wang, Deyan Luo, Hui Wang Front Immunol. 2020; 11: 608895. Published online 2021 Feb 23. doi: 10.3389/fimmu.2020.608895 PMCID: PMC7940682
Plasma BCAA concentrations during exercise of varied intensities in young healthy men—the impact of endurance training Anna Gawedzka, Marcin Grandys, Krzysztof Duda, Justyna Zapart-Bukowska, Jerzy A. Zoladz, Joanna Majerczak PeerJ. 2020; 8: e10491. Published online 2020 Dec 21. doi: 10.7717/peerj.10491 PMCID: PMC7759138
Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion Phillip J. White, Amanda L. Lapworth, Robert W. McGarrah, Lydia Coulter Kwee, Scott B. Crown, Olga Ilkayeva, Jie An, Matthew W. Carson, Bridgette A. Christopher, James R. Ball, Michael N. Davies, Lilja Kjalarsdottir, Tabitha George, Michael J. Muehlbauer, James R. Bain, Robert D. Stevens, Timothy R. Koves, Deborah M. Muoio, Joseph T. Brozinick, Ruth E. Gimeno, M. Julia Brosnan, Timothy P. Rolph, William E. Kraus, Svati H. Shah, Christopher B. Newgard Cell Rep. Author manuscript; available in PMC 2021 Oct 6.Published in final edited form as: Cell Rep. 2020 Nov 10; 33(6): 108375. doi: 10.1016/j.celrep.2020.108375 PMCID: PMC8493998
Lipid changes in the metabolome of a single case study with maple syrup urine disease (MSUD) after five days of improved diet adherence of controlled branched-chain amino acids (BCAA) Teresa D. Douglas, L. Kristin Newby, Julie Eckstrand, Douglas Wixted, Rani H. Singh Mol Genet Metab Rep. 2020 Dec; 25: 100651. Published online 2020 Oct 14. doi: 10.1016/j.ymgmr.2020.100651 PMCID: PMC7567947
MiR-125a-3p-KLF15-BCAA Regulates the Skeletal Muscle Branched-Chain Amino Acid Metabolism in Nile Tilapia (Oreochromis niloticus) During Starvation Honghui Li, Xiaoling An, Lingsheng Bao, Yulong Li, Yaxiong Pan, Jinggang He, Li Liu, Xin Zhu, Jianshe Zhang, Jia Cheng, Wuying Chu Front Genet. 2020; 11: 852. Published online 2020 Aug 11. doi: 10.3389/fgene.2020.00852 PMCID: PMC7431957
Determining Ideal Balance Among Branched-Chain Amino Acids (BCAA) as a Proof of Concept Study in Healthy Children Haneen Saleemani, Rajavel Elango, Gabriella Horvath, Sylvia Stockler Curr Dev Nutr. 2020 Jun; 4(Suppl 2): 1068. Published online 2020 May 29. doi: 10.1093/cdn/nzaa054_140 PMCID: PMC7258088
Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth Ming-Zhu Lei, Xu-Xu Li, Ye Zhang, Jin-Tao Li, Fan Zhang, Yi-Ping Wang, Miao Yin, Jia Qu, Qun-Ying Lei Signal Transduct Target Ther. 2020; 5: 70. Published online 2020 May 29. doi: 10.1038/s41392-020-0168-0 PMCID: PMC7256045
Effects of Branched-Chain Amino Acid (BCAA) Supplementation on the Progression of Advanced Liver Disease: A Korean Nationwide, Multicenter, Prospective, Observational, Cohort Study Jung Gil Park, Won Young Tak, Soo Young Park, Young Oh Kweon, Woo Jin Chung, Byoung Kuk Jang, Si Hyun Bae, Heon Ju Lee, Jae Young Jang, Ki Tae Suk, Myung Jin Oh, Jeong Heo, Hyun Young Woo, Se Young Jang, Yu Rim Lee, June Sung Lee, Do Young Kim, Seok Hyun Kim, Jeong Ill Suh, In Hee Kim, Min Kyu Kang, Won Kee Lee Nutrients. 2020 May; 12(5): 1429. Published online 2020 May 15. doi: 10.3390/nu12051429 PMCID: PMC7284598
Consumption of a Branched-Chain Amino Acid (BCAA) during Days 2–10 of Pregnancy Causes Abnormal Fetal and Placental Growth: Implications for BCAA Supplementation in Humans Chiu Yuen To, Muriel Freeman, Lon J. Van Winkle Int J Environ Res Public Health. 2020 Apr; 17(7): 2445. Published online 2020 Apr 3. doi: 10.3390/ijerph17072445 PMCID: PMC7178017
Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer Qin Tian, Ping Yuan, Chuntao Quan, Mingyang Li, Juanjuan Xiao, Lu Zhang, Hui Lu, Tengfei Ma, Ling Zou, Fei Wang, Peipei Xue, Xiaofang Ni, Wei Wang, Lin Liu, Zhe Wang, Feng Zhu, Qiuhong Duan Oncogene. 2020; 39(20): 3980–3996. Published online 2020 Apr 1. doi: 10.1038/s41388-020-1262-z PMCID: PMC7220852
Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets Jinghui Heng, Zhihui Wu, Min Tian, Jiaming Chen, Hanqing Song, Fang Chen, Wutai Guan, Shihai Zhang Nutr Metab (Lond) 2020; 17: 10. Published online 2020 Jan 23. doi: 10.1186/s12986-019-0424-x PMCID: PMC6979292
BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice Ji Wang, Yunxia Liu, Kun Lian, Xinyi Shentu, Junwei Fang, Jing Shao, Mengping Chen, Yibin Wang, Meiyi Zhou, Haipeng Sun Front Physiol. 2019; 10: 1140. Published online 2019 Sep 4. doi: 10.3389/fphys.2019.01140 PMCID: PMC6738029
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44 Takeshi Yoneshiro, Qiang Wang, Kazuki Tajima, Mami Matsushita, Hiroko Maki, Kaori Igarashi, Zhipeng Dai, Phillip J. White, Robert W. McGarrah, Olga R Ilkayeva, Yann Deleye, Yasuo Oguri, Mito Kuroda, Kenji Ikeda, Huixia Li, Ayano Ueno, Maki Ohishi, Takamasa Ishikawa, Kyeongkyu Kim, Yong Chen, Carlos Henrique Sponton, Rachana N. Pradhan, Homa Majd, Vanille Juliette Greiner, Momoko Yoneshiro, Zachary Brown, Maria Chondronikola, Haruya Takahashi, Tsuyoshi Goto, Teruo Kawada, Labros Sidossis, Francis C. Szoka, Michael T. McManus, Masayuki Saito, Tomoyoshi Soga, Shingo Kajimura Nature. Author manuscript; available in PMC 2020 Feb 21.Published in final edited form as: Nature. 2019 Aug; 572(7771): 614–619. Published online 2019 Aug 21. doi: 10.1038/s41586-019-1503-x PMCID: PMC6715529
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance Meiyi Zhou, Jing Shao, Cheng-Yang Wu, Le Shu, Weibing Dong, Yunxia Liu, Mengping Chen, R. Max Wynn, Jiqiu Wang, Ji Wang, Wen-Jun Gui, Xiangbing Qi, Aldons J. Lusis, Zhaoping Li, Weiqing Wang, Guang Ning, Xia Yang, David T. Chuang, Yibin Wang, Haipeng Sun Diabetes. 2019 Sep; 68(9): 1730–1746. Published online 2019 Aug 14. doi: 10.2337/db18-0927 PMCID: PMC6702639
Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation Zhimin Gu, Yuxuan Liu, Feng Cai, McKenzie Patrick, Jakub Zmajkovic, Hui Cao, Yuannyu Zhang, Alpaslan Tasdogan, Mingyi Chen, Le Qi, Xin Liu, Kailong Li, Junhua Lyu, Kathryn E. Dickerson, Weina Chen, Min Ni, Matthew E. Merritt, Sean J. Morrison, Radek C. Skoda, Ralph J. DeBerardinis, Jian Xu Cancer Discov. Author manuscript; available in PMC 2020 Mar 1.Published in final edited form as: Cancer Discov. 2019 Sep; 9(9): 1228–1247. Published online 2019 Jun 12. doi: 10.1158/2159-8290.CD-19-0152 PMCID: PMC6726547
Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity Russell E. Ericksen, Weiping Han Mol Cell Oncol. 2019; 6(3): 1585171. Published online 2019 Mar 20. doi: 10.1080/23723556.2019.1585171 PMCID: PMC6512911
Loss of BCAA catabolism during carcinogenesis enhances mTORCl activity and promotes tumor development and progression Russell E. Ericksen, Siew Lan Lim, Eoin McDonnell, Wai Ho Shuen, Maya Vadiveloo, Phillip J. White, Zhaobing Ding, Royston Kwok, Philip Lee, George K. Radda, Han Chong Toh, Matthew D. Hirschey, Weiping Han Cell Metab. Author manuscript; available in PMC 2020 May 7.Published in final edited form as: Cell Metab. 2019 May 7; 29(5): 1151–1165.e6. Published online 2019 Jan 17. doi: 10.1016/j.cmet.2018.12.020 PMCID: PMC6506390
Associations Between Dietary Protein Sources, Plasma BCAA and Short-Chain Acylcarnitine Levels in Adults Michèle Rousseau, Frédéric Guénard, Véronique Garneau, Bénédicte Allam-Ndoul, Simone Lemieux, Louis Pérusse, Marie-Claude Vohl Nutrients. 2019 Jan; 11(1): 173. Published online 2019 Jan 15. doi: 10.3390/nu11010173 PMCID: PMC6356602
BCAT1 promotes proliferation of endometrial cancer cells through reprogrammed BCAA metabolism Ping Wang, Shouheng Wu, Xiaofeng Zeng, Yaqing Zhang, Ying Zhou, Liuli Su, Wei Lin Int J Clin Exp Pathol. 2018; 11(12): 5536–5546. Published online 2018 Dec 1. PMCID: PMC6963089
The pattern of plasma BCAA concentration and liver Bckdha gene expression in GK rats during T2D progression Wenlu Zhang, Yu'e Wu, Wei Fan, Hongmei Chen, Hongli Du, Junhua Rao Animal Model Exp Med. 2018 Dec; 1(4): 305–313. Published online 2018 Nov 13. doi: 10.1002/ame2.12038 PMCID: PMC6388062
The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase Phillip J. White, Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan Haldeman, Thomas Grenier-Larouche, Jie An, Amanda L Lapworth, Inna Astapova, Sarah A. Hannou, Tabitha George, Michelle Arlotto, Lyra B. Olson, Michelle Lai, Guofang Zhang, Olga Ilkayeva, Mark A. Herman, R. Max Wynn, David T. Chuang, Christopher B. Newgard Cell Metab. Author manuscript; available in PMC 2019 Jun 5.Published in final edited form as: Cell Metab. 2018 Jun 5; 27(6): 1281–1293.e7. Published online 2018 May 17. doi: 10.1016/j.cmet.2018.04.015 PMCID: PMC5990471
Dietary Pattern and Plasma BCAA-Variations in Healthy Men and Women—Results from the KarMeN Study Benedikt Merz, Lara Frommherz, Manuela J. Rist, Sabine E. Kulling, Achim Bub, Bernhard Watzl Nutrients. 2018 May; 10(5): 623. Published online 2018 May 15. doi: 10.3390/nu10050623 PMCID: PMC5985475
Anti-inflammatory and anti-genotoxic activity of branched chain amino acids (BCAA) in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages Jae Hoon Lee, Eunju Park, Hyue Ju Jin, Yunjeong Lee, Seung Jun Choi, Gyu Whan Lee, Pahn-Shick Chang, Hyun-Dong Paik Food Sci Biotechnol. 2017; 26(5): 1371–1377. Published online 2017 Aug 18. doi: 10.1007/s10068-017-0165-4 PMCID: PMC6049802
An exploratory study on the efficacy and safety of a BCAA preparation used in combination with cardiac rehabilitation for patients with chronic heart failure Munenori Takata, Eisuke Amiya, Masafumi Watanabe, Yumiko Hosoya, Atsuko Nakayama, Takayuki Fujiwara, Masanobu Taya, Gaku Oguri, Kanako Hyodo, Naoko Takayama, Nami Takano, Tomoe Mashiko, Yukari Uemura, Issei Komuro BMC Cardiovasc Disord. 2017; 17: 205. Published online 2017 Jul 27. doi: 10.1186/s12872-017-0639-6 PMCID: PMC5531093
Cancer progression by reprogrammed BCAA metabolism in myeloid leukemia Ayuna Hattori, Makoto Tsunoda, Takaaki Konuma, Masayuki Kobayashi, Tamas Nagy, John Glushka, Fariba Tayyari, Daniel McSkimming, Natarajan Kannan, Arinobu Tojo, Arthur S. Edison, Takahiro Ito Nature. Author manuscript; available in PMC 2017 Nov 17.Published in final edited form as: Nature. 2017 May 25; 545(7655): 500–504. Published online 2017 May 17. doi: 10.1038/nature22314 PMCID: PMC5554449
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer Peipei Xue, Fanfan Zeng, Qiuhong Duan, Juanjuan Xiao, Lin Liu, Ping Yuan, Linni Fan, Huimin Sun, Olesya S. Malyarenko, Hui Lu, Ruijuan Xiu, Shaoqing Liu, Chen Shao, Jianmin Zhang, Wei Yan, Zhe Wang, Jianyong Zheng, Feng Zhu EBioMedicine. 2017 Jun; 20: 50–60. Published online 2017 May 4. doi: 10.1016/j.ebiom.2017.05.001 PMCID: PMC5478211
Dietary BCAA Intake Is Associated with Demographic, Socioeconomic and Lifestyle Factors in Residents of São Paulo, Brazil Ana Carolina Pallottini, Cristiane Hermes Sales, Diva Aliete dos Santos Vieira, Dirce Maria Marchioni, Regina Mara Fisberg Nutrients. 2017 May; 9(5): 449. Published online 2017 May 2. doi: 10.3390/nu9050449 PMCID: PMC5452179
Defective Branched-Chain Amino Acid (BCAA) Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-reperfusion Injury Tao Li, Zhen Zhang, Stephen C Kolwicz, Jr, Lauren Abell, Nathan D. Roe, Maengjo Kim, Bo Zhou, Yang Cao, Julia Ritterhoff, Haiwei Gu, Daniel Raftery, Haipeng Sun, Rong Tian Cell Metab. Author manuscript; available in PMC 2018 Feb 7.Published in final edited form as: Cell Metab. 2017 Feb 7; 25(2): 374–385. doi: 10.1016/j.cmet.2016.11.005 PMCID: PMC5301464
Liver BCATm transgenic mouse model reveals the important role of the liver in maintaining BCAA homeostasis Elitsa A. Ananieva, Cynthia G. Van Horn, Meghan R. Jones, Susan M. Hutson J Nutr Biochem. Author manuscript; available in PMC 2018 Feb 1.Published in final edited form as: J Nutr Biochem. 2017 Feb; 40: 132–140. Published online 2016 Nov 2. doi: 10.1016/j.jnutbio.2016.10.014 PMCID: PMC5235979
The Effect of BCAA and ISO-WHEY Oral Nutritional Supplements on Dialysis Adequacy Effat Afaghi, Ali Tayebi, Abbas Ebadi, Vahid Sobhani, Behzad Einollahi, Mehdi Tayebi Nephrourol Mon. 2016 Nov; 8(6): e34993. Published online 2016 Sep 5. doi: 10.5812/numonthly.34993 PMCID: PMC5120366
Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD Davis S. Sonnet, Monique N. O’Leary, Mark A. Gutierrez, Steven M. Nguyen, Samiha Mateen, Yuehmei Hsu, Kylie P. Mitchell, Antonio J. Lopez, Jerry Vockley, Brian K. Kennedy, Arvind Ramanathan Sci Rep. 2016; 6: 28775. Published online 2016 Jul 4. doi: 10.1038/srep28775 PMCID: PMC4931503
The data do not seem to support a benefit to BCAA supplementation during periods of caloric restriction Brad P. Dieter, Brad Jon Schoenfeld, Alan A. Aragon J Int Soc Sports Nutr. 2016; 13: 21. Published online 2016 May 11. doi: 10.1186/s12970-016-0128-9 PMCID: PMC4865017
Nanoparticles Suitable for BCAA Isolation Can Serve for Use in Magnetic Lipoplex-Based Delivery System for L, I, V, or R-rich Antimicrobial Peptides Radek Vesely, Pavlina Jelinkova, Dagmar Hegerova, Natalia Cernei, Pavel Kopel, Amitava Moulick, Lukas Richtera, Zbynek Heger, Vojtech Adam, Ondrej Zitka Materials (Basel) 2016 Apr; 9(4): 260. Published online 2016 Mar 31. doi: 10.3390/ma9040260 PMCID: PMC5502924
Dataset reporting BCKDK interference in a BCAA-catabolism restricted environment I. Bravo-Alonso, A. Oyarzabal, M. Sánchez-Aragó, M.T. Rejas, B. Merinero, A. García-Cazorla, R. Artuch, M. Ugarte, P. Rodríguez-Pombo Data Brief. 2016 Jun; 7: 755–759. Published online 2016 Mar 15. doi: 10.1016/j.dib.2016.03.038 PMCID: PMC4804226
Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer’s disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels Henry H. Ruiz, Tiffany Chi, Andrew C. Shin, Claudia Lindtner, Wilson Hsieh, Michelle Ehrlich, Sam Gandy, Christoph Buettner Alzheimers Dement. Author manuscript; available in PMC 2017 Aug 1.Published in final edited form as: Alzheimers Dement. 2016 Aug; 12(8): 851–861. Published online 2016 Feb 28. doi: 10.1016/j.jalz.2016.01.008 PMCID: PMC5358328
Acetohydroxyacid synthase FgIlv2 and FgIlv6 are involved in BCAA biosynthesis, mycelial and conidial morphogenesis, and full virulence in Fusarium graminearum Xin Liu, Qi Han, Jianhong Xu, Jian Wang, Jianrong Shi Sci Rep. 2015; 5: 16315. Published online 2015 Nov 10. doi: 10.1038/srep16315 PMCID: PMC4639788
The Impaired Function of Macrophages Induced by Strenuous Exercise Could Not Be Ameliorated by BCAA Supplementation Weihua Xiao, Peijie Chen, Xiaoguang Liu, Linlin Zhao Nutrients. 2015 Oct; 7(10): 8645–8656. Published online 2015 Oct 21. doi: 10.3390/nu7105425 PMCID: PMC4632445
Dexamethasone and BCAA Failed to Modulate Muscle Mass and mTOR Signaling in GH-Deficient Rats Hikaru Nishida, Ayaka Ikegami, Chiaki Kaneko, Hitomi Kakuma, Hisano Nishi, Noriko Tanaka, Michiko Aoyama, Makoto Usami, Yasuhiko Okimura PLoS One. 2015; 10(6): e0128805. Published online 2015 Jun 18. doi: 10.1371/journal.pone.0128805 PMCID: PMC4472719
Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism Andrew C. Shin, Martin Fasshauer, Nika Filatova, Linus A. Grundell, Elizabeth Zielinski, Jian-Ying Zhou, Thomas Scherer, Claudia Lindtner, Phillip J. White, Amanda L. Lapworth, Olga Ilkayeva, Uwe Knippschild, Anna M. Wolf, Ludger Scheja, Kevin L. Grove, Richard D. Smith, Wei-Jun Qian, Christopher J. Lynch, Christopher B. Newgard, Christoph Buettner Cell Metab. Author manuscript; available in PMC 2015 Nov 4.Published in final edited form as: Cell Metab. 2014 Nov 4; 20(5): 898–909. Published online 2014 Oct 9. doi: 10.1016/j.cmet.2014.09.003 PMCID: PMC4254305
Effects of Supplementation with BCAA and L-glutamine on Blood Fatigue Factors and Cytokines in Juvenile Athletes Submitted to Maximal Intensity Rowing Performance Ga Hee Koo, Jinhee Woo, Sungwhun Kang, Ki Ok Shin J Phys Ther Sci. 2014 Aug; 26(8): 1241–1246. Published online 2014 Aug 30. doi: 10.1589/jpts.26.1241 PMCID: PMC4155228
Two randomized controlled studies comparing the nutritional benefits of branched-chain amino acid (BCAA) granules and a BCAA-enriched nutrient mixture for patients with esophageal varices after endoscopic treatment Yoshiyuki Sakai, Yoshinori Iwata, Hirayuki Enomoto, Masaki Saito, Kazunori Yoh, Akio Ishii, Tomoyuki Takashima, Nobuhiro Aizawa, Naoto Ikeda, Hironori Tanaka, Hiroko Iijima, Shuhei Nishiguchi J Gastroenterol. 2015; 50(1): 109–118. Published online 2014 Mar 17. doi: 10.1007/s00535-014-0950-2 PMCID: PMC4286625
Effect of BCAA intake during endurance exercises on fatigue substances, muscle damage substances, and energy metabolism substances Dong-Hee Kim, Seok-Hwan Kim, Woo-Seok Jeong, Ha-Yan Lee J Exerc Nutrition Biochem. 2013 Dec; 17(4): 169–180. Published online 2013 Nov 28. doi: 10.5717/jenb.2013.17.4.169 PMCID: PMC4241904
Characterization of BcaA, a Putative Classical Autotransporter Protein in Burkholderia pseudomallei Cristine G. Campos, Luke Borst, Peggy A. Cotter Infect Immun. 2013 Apr; 81(4): 1121–1128. doi: 10.1128/IAI.01453-12 PMCID: PMC3639613
Exercise x BCAA Supplementation in Young Trained Rats: What are their Effects on Body Growth? Patricia Lopes de Campos-Ferraz, Sandra Maria Lima Ribeiro, Silmara dos Santos Luz, Antonio Herbert Lancha Jr., Jr., Julio Tirapegui J Sports Sci Med. 2011 Sep; 10(3): 483–490. Published online 2011 Sep 1. PMCID: PMC3737814
Effect of Oral Supplementation with Branched-chain Amino Acid (BCAA) during Radiotherapy in Patients with Hepatocellular Carcinoma: A Double-Blind Randomized Study Ik Jae Lee, Jinsil Seong, Jung Im Bae, Sei Hwan You, Yumie Rhee, Jong Ho Lee Cancer Res Treat. 2011 Mar; 43(1): 24–31. Published online 2011 Mar 31. doi: 10.4143/crt.2011.43.1.24 PMCID: PMC3072532
Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance Pengxiang She, Yingsheng Zhou, Zhiyou Zhang, Kathleen Griffin, Kavitha Gowda, Christopher J. Lynch J Appl Physiol (1985) 2010 Apr; 108(4): 941–949. Published online 2010 Feb 4. doi: 10.1152/japplphysiol.01248.2009 PMCID: PMC2853195
Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels Mark A. Herman, Pengxiang She, Odile D. Peroni, Christopher J. Lynch, Barbara B. Kahn J Biol Chem. 2010 Apr 9; 285(15): 11348–11356. Published online 2010 Jan 21. doi: 10.1074/jbc.M109.075184 PMCID: PMC2857013
The anabolic hormone response to a lower-body resistance exercise bout in conjunction with oral BCAA supplementation Bill Campbell, Paul La Bounty, Austin Oetken, Mike Greenwood, Richard Kreider, Darryn Willoughby J Int Soc Sports Nutr. 2009; 6(Suppl 1): P7. Published online 2009 Jul 31. doi: 10.1186/1550-2783-6-S1-P7 PMCID: PMC3313168
The effect of BCAA supplementation on serum insulin secretion before, during, and following a lower-body resistance exercise bout Austin Oetken, Bill Campbell, Paul La Bounty, Darryn Willoughby J Int Soc Sports Nutr. 2008; 5(Suppl 1): P20. Published online 2008 Sep 17. doi: 10.1186/1550-2783-5-S1-P20 PMCID: PMC3313104
The effects of BCAA and leucine supplementation and lower-body resistance exercise on the ERK 1/2 MAPK pathway signal transduction Bill Campbell, Paul La Bounty, Austin Oetken, Darryn Willoughby J Int Soc Sports Nutr. 2008; 5(Suppl 1): P19. Published online 2008 Sep 17. doi: 10.1186/1550-2783-5-S1-P19 PMCID: PMC3313102
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched chain amino acid (BCAA) metabolism Pengxiang She, Cynthia Van Horn, Tanya Reid, Susan M. Hutson, Robert N. Cooney, Christopher J. Lynch Am J Physiol Endocrinol Metab. Author manuscript; available in PMC 2009 Oct 26.Published in final edited form as: Am J Physiol Endocrinol Metab. 2007 Dec; 293(6): E1552–E1563. Published online 2007 Oct 9. doi: 10.1152/ajpendo.00134.2007 PMCID: PMC2767201
The effects of the formula of amino acids enriched BCAA on nutritional support in traumatic patients Xin-Ying Wang, Ning Li, Jun Gu, Wei-Qin Li, Jie-Shou Li World J Gastroenterol. 2003 Mar 15; 9(3): 599–602. Published online 2003 Mar 15. doi: 10.3748/wjg.v9.i3.599 PMCID: PMC4621590
Administration of balanced or BCAA-enriched amino acid solution in septic rats. Effects on protein synthesis in the liver. P Pedersen, S J Li, P O Hasselgren, R LaFrance, J E Fischer Ann Surg. 1988 Dec; 208(6): 714–720. doi: 10.1097/00000658-198812000-00007 PMCID: PMC1493827
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